I haven't done too many break up comics (well... I've drawn a fair amount)(but I haven't posted many)(yet), but the responses I get can be broken into two categories. From people my age or younger I tend to get comments along the lines of, "Right on," or, "That's the stuff, man," or something to that extent. From people who are bit older than me or from my parent's generation I get comments that are more like, "Oh, that's so depressing!" or, "Are you all right?" or, "Have you thought about seeing a psychologist?"
It's an interesting dichotomy.